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It has also been observed that the GS-ylation of SirT1 inhibits its activity contributing to the onset of thoracic aortic aneurysm in Marfan syndrome

This is close to the region where intracellular toxic metals are present in the superficial cortex adjacent to leptomeningeal venules (Figure 4E)

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Griffiths T.W., Watson R.E.B., Langton A.K

These data are of interest to malaria control programs as well as researchers, and include complexity of infection estimates, transmission network inference, mutation frequencies in antimalarial resistance orthologs, and balancing selection in potential blood-stage vaccine targets that may hinder the development and deployment of such vaccines