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Green tea polyphenols as proteasome inhibitors: implication in chemoprevention

Specifically, EGFR activation triggers ERK-mediated phosphorylation and nuclear translocation of ACSS2, which binds to KAT2A, functioning as a lactyltransferase to promote H3K14/18la and facilitating Wnt/b-catenin, NF-kB, and PD-L1 expression

Several open-label studies including patients with antiretroviral toxic neuropathy have been carried out

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