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Once it gives that electron away to neutralise a free radical, it becomes "oxidised" (GSSG) and must be recycled back to its reduced state to be useful again
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Therapeutic strategies can therefore be envisioned to increase choroidal neuroprotective functions in perinatal conditions in which choroidal detoxifying systems may be sub-optimal, or when the brain is facing adverse oxidative and chemical stresses, such as exposure to pharmacological agents or environmental toxicants, hypoxia, and hyperbilirubinemia
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages
