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Description
402,403,404,405 The liver-specific deletion of both AKT1 and AKT2 inhibits hepatocyte proliferation along with glucose intolerance and insulin resistance
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First description in humans of the ability of SGLT2 inhibitors to attenuate glomerular hyperfiltration, likely by affecting tubuloglomerular feedback mechanisms

Their small, linear structures facilitate easier synthesis, high water solubility, and effective diffusion across biological barriers
