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doi: 10.1073/pnas.2213207120
The culmination of all of these studies come to light with the finding of several (some reported and many from our group still publication pending) Larons Syndrome (congenital IGF-1 deficiency or GH insensitivity) never treated patients who underwent progression to MetS and ultimately to T2D together with diabetic retinopathy when they reached their late 30 s, [250, 251]
E.ZhaoJ.RoneJ
Next-generation compounds like survodutide , CagriSema , and orforglipron are also entering the landscape, though most are not yet available in compounded formulations
