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[24] of the potential adverse effects of caffeine consumption on healthy adults, pregnant women, adolescents, and children, the daily safe dose of caffeine whose combined adult intake of various dietary products was not associated with an increased risk of adverse effects was 400 mg

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Some examples of drugs that are eliminated by active tubular secretion include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see WARNINGS AND PRECAUTIONS ]