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One of the investigations reported that NPs were loaded with nuclear factor kappa B (NF-B) inhibitors, a key regulator of inflammation, which could suppress the microglial activation and decrease the production of pro-inflammatory cytokines

Science 340 , 879882 (2013)

Of note, GPX4 deficient mice are not viable and die at embryonic day 8 [3, 4]

Innovations in drug delivery systems, such as advanced nanocarriers and novel intrathecal formulations, are actively being explored to overcome the biodistribution and bioavailability barriers specific to the CNS, which are crucial for both biological therapeutics and small molecules (69)