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Both total iron and areal density increased with age in control animals ( Figure 3B & C

This effect effectively inhibits downstream MyD88-dependent signal transduction, reduces the phosphorylation of the NF-Bp65 subunit and blocks its nuclear translocation, and ultimately significantly downregulates the expression of inflammatory mediators such as COX-2 and iNOS, as well as pro-inflammatory factors such as IL-6 and TNF-

Pearson et al., 2021), and this may also apply for the semisynthetic variants

Interestingly, CD8 + T cells also influence the TME by altering the metabolic landscape of surrounding stromal cells