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GHRP-2 works by triggering the pituitary gland to enhance levels of HGH production and cause growth hormone release into the bloodstream

On the other hand, EGCG was shown to effectively attenuate the activity of dihydrofolate reductase (DHFR) and disrupt the folate cycle, thereby diminishing the cellular production of nucleotides by damaging the one-carbon pool (237, 238)

Braak H, Braak E, Bohl J

Impaired kidney function is also associated with increased IGFBP levels (e.g., IGFBP-1, -2, -3, -4, and -6) (75, 77) and IGFBP-3 protease activity, which subsequently increases low-molecular-weight IGFBP-3 fragments (78), most likely due to a compromised renal IGFBP-clearance ( Figure 4 )