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References are included at the end of the article when scientific, medical, or health-related claims are discussed

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Joint pain developing after starting B12 may reflect: Pre-existing musculoskeletal conditions becoming more noticeable Concurrent inflammatory or degenerative joint disease Reactions to excipients in certain formulations The natural course of an underlying condition If you experience persistent or worsening joint symptoms after beginning B12 supplementation, it is advisable to consult your GP or healthcare provider

They are stable at higher temperatures and under acidic conditions, which may be required for conjugation to radionuclides