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Nevertheless, the current understanding of the potential association between CM and the gut-brain axis (GBA) is based solely on indirect inferences drawn from existing literature

This understanding has led to the development of antifolate drugs and targeted therapies for FOLRs, which have become fundamental therapeutic alternatives in oncology

Higuchi N, Kato M, Tanaka M, Miyazaki M, Takao S, Kohjima M, Kotoh K, Enjoji M, Nakamuta M, Takayanagi R (2011) Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease

In this review, we discuss the molecular mechanisms that modulate 1, - 2 -, and -AR desensitization