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Il est prsent dans presque toutes les cellules et joue un rle central dans lquilibre cellulaire
Newman and colleagues developed one of the first LC-MS profiling methods for linoleate and arachidonate derived epoxides and vicinal diols in 2002, 417 measuring 13 oxylipins in 31 min with LOQ 1.5 nM
The incidence of renal failure in clinical studies in which patients received ALIMTA as a single agent ranged from 0.4% to 0.6% (Studies JMEN, PARAMOUNT, and JMEI [see Adverse Reactions (6.1)]
