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The essential nature of this reaction was established with the development of GGT knockout strains of mouse (Lieberman et al., 1996)

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While glutathione is included in the treatment of many diseases, its effects on them have not been definitively proven

As described above, the vocal fold mucosa is so thin and delicate that it can be damaged easily by overuse (vocal abuse), inflammation caused by upper respiratory infection, smoking, inhalation of chemical pollution, or allergy as well as direct injury by burn, radiation, or surgery to the vocal fold [10,11]