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Another recent multicentre placebo-controlled trial of vitamin C and E in women with type-1 diabetes in pregnancy (DAPIT) also reported no differences in the rates of preeclampsia between supplemented or placebo groups [133]

Therefore, enhanced glutaminolysis might eventually contribute to the initiation and progression of cancer by stimulating cell growth via the mTORC1 pathway and enhancing aerobic glycolysis while disrupting the proper elimination of misfolded proteins, damaged DNA and organelles through the inhibition of autophagy and the DNA damage response 166

Supplement dose for vitamin B12 in post-WLS patients varies based on the route of administration: Orally by disintegrating tablet, sublingual (under the tongue), or liquid: 350500 mg daily Nasal spray as directed by manufacturer Parenteral (IM or SQ): 1000 mg monthly Post-WLS patients with B12 deficiency should take 1000 mg/d to achieve normal levels and then resume dosages recommended to maintain normal levels

10.1111/nph.18437 183 WangC.YangF.ZengW.ChenX.QiuZ.WangQ.et al (2024a)