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In contrast, the full (liposome-encapsulated) plasma level of ribavirin in EYPC-based liposomes (again after a single intravenous injection of 50 mg/kg in rats) was found to peak at only 1 millimolar and to rapidly decline (with a half-life of about 3 hours), with no observed difference between the 0 and 2% GSH on the outer surface of the liposomes
Dual localization of the gene product in these two compartments has also been demonstrated in Arabidopsis (Chew et al., 2003)
Top scorers were then analyzed for drug potentiation experimentally and their mechanisms of action were determined
[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Chen Y., Azad M.B., Gibson S.B
