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doi: 10.1016/0166-2236(89)90074-X

It has been shown to improve acne vulgaris by affecting neutrophil chemotaxis and suppresses cytokine-mediated induction of nitric oxide synthase

The body essentially adapts to the presence of the signaling molecule and requires increasingly higher doses to achieve the same effect

doi: 10.1016/j.phytochem.2011.02.012 230
