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[21] and Singh et al

Based on its nucleoside analogue structure, it is tempting to speculate that the drug could impair mitochondrial DNA replication and induce a mitohormetic response ( Taken together, the various effects of rapamycin and adefovir dipivoxil observed here suggest that modulating the expression of both C/EBP- isoforms, LAP and LIP, is likely critical for nutrient homeostasis
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