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PubMed Central , Integrative Medicine: A Clinicians Journal , vol

The ability of melatonin to cross the BBB and act directly on the brain makes it a particularly attractive candidate for treating BBB dysfunction ( 7.2.1.2 Statins Statins, commonly used for lowering cholesterol, have also shown potential in protecting BBB integrity

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These usually develop gradually, but can worsen if the condition goes untreated
