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The passive pressure-diameter relationship in middle cerebral arteries that were maximally dilated with Ca 2+ free solution was also similar in S-D rats fed HS diet and LS Diet Protandim (Supplement Figure 2), demonstrating that HS diet and/or Protandim treatment had no effect on the passive mechanical properties of the arteries

doi: 10.1016/j.freeradbiomed.2020.10.002 128 JarrottB.HeadR.PringleK

Improvement in neuropathy outcomes with normalizing HbA1c in patients with type 2 diabetes

68 Of note, the BNIP3/NIX pathway was specifically up-regulated when mitochondrial oxidative stress was generated in the hypoxic environment to further induce mitophagy