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Key takeaways Hyaluronic acid (HA) dental fillers promote collagen synthesis, fibroblast activity, and tissue regeneration while reducing inflammation and restoring gum contour

The NOX-generated superoxide can be converted to other forms of ROS or detoxified by reduced glutathione and glutathione-coupled antioxidant enzymes, such as glutathione peroxidases (GPXs) and glutathione reductase (GR), to maintain redox homeostasis

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This thereby accelerates lipid peroxidation and hepatocyte death, ultimately contributing to hepatic inflammation and fibrosis [53]