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When you supplement methylfolate the body will clear a backlog of incomplete metabolic processes resulting in increased mobilisation and discharge of toxins and to avoid a healing reaction the 1 In addition to paving the way for detoxification you should use supplements to build up the other essential mineral and vitamin methyl donors (mentioned above) needed for complete methylation Sometimes its a good idea to start with phospholipids such as phosphatidylserine, phosphatidylcholine, pure choline et al, these provide a shortcut to supplying methyl groups to where they are needed compared to the long methylfolate metabolic path