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Weeks 8 to 16: Body composition

This effect occurs through a ROS-dependent mild mitochondrial ribosomal stress, which in turn triggers unfolded protein responses (UPR mt ) and thermogenesis in adipose tissue, promoting a high-turnover metabolism and increase resistance to obesity in mice

Non-transferrin-bound iron (NTBI) can enter cells via the zinc transporters ZIP8 (SLC39A8) and ZIP14 (SLC39A14) [20,21], while iron bound to the extracellular matrix polysaccharide, hyaluronan, is proposed to bind CD44, with the resulting complex being taken up by endocytosis [22]

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