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In response to cisplatin, ATX-LPN can block the secretion of cytochrome c and cleaved caspase-3/9
However, the relevance of the anti-fibrotic effects of NAC has not been clearly confirmed yet in the clinical studies in patients with IPF [5,19,78,79,80] or with lung silicosis [50,81]
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ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers
