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Ideal persons to receive these injections are people who have undergone plastic surgery and are unable to absorb vitamin B12 in the body

This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur

Neurological Research, 46 (2), 165-177

Whenever people find it difficult to maintain adequate vitamin B12 levels, either because they have an absorption problem or follow a vegan or vegetarian diet, B12 supplements often come to their aid