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Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]
doi: 10.1038/s41598-017-11744-6 94
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Muscle Oxygen Supply L-carnitine can improve blood flow, enhancing nutrient and oxygen delivery to muscles during workouts, which is essential for performance and recovery
