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Engineering College, India Tran Viet Dung, Ho Chi Minh City University of Law, Vietnam Data availability statement The datasets presented in this study can be found in online repositories

This chemical irritation is caused by the AN constituents, which include alkaloids, flavonoids, tannins, carbohydrates, proteins, and fats, with arecoline and arecaidine (alkaloids) being the most irritating, causing abnormal collagen accumulation

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