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Similar to the CYP450 enzymes, genetic polymorphisms can have profound influence on the function of these conjugating enzymes [82], with potential implication in the development of several forms of cancer [83]

The primary underlying pathomechanism is most likely a decreased hepatic GHR expression related to insulin deficiency, resulting in GH-resistance and impaired hepatic IGF-1 synthesis, which stimulates pituitary GH-secretion by a feedback mechanism [188, 189]

Furthermore, the expression of DRP1 was observed at the protein level rather than at the gene level, and mitophagy levels were evaluated by LC3 and p62, which are not exclusive markers of mitophagy but are shared with general autophagy

11 , e37576 (2022)