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The activation of this endogenous opioid system, which is responsible for severe respiratory depression, gastrointestinal motility inhibition and pinpoint pupils, is not observed in running athletes

Regarding PAHs, while glucuronidation by UGT enhances their solubility for excretion, some incompletely metabolized PAH products may persist and bind to bladder DNA, forming adducts that increase the risk of mutations and the development of bladder cancer (Girard et al., 2008)

Indeed, a ferroptotic stress was shown to be able to activate ROS feedback loops, resulting in long-distance ROS propagation [15]

in the treatment of patients with abnormal uterine bleeding: a pilot clinical trial