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For example, complete loss of PGRN leads to Neuronal Ceroid Lipofuscinosis 67,68 , a neurodegenerative disease characterized by lysosomal accumulation of lipofuscin, a lipid-protein aggregate

While the increase of membrane bending rigidity is probably sufficient to inhibit lipid droplet formation, vesicle formation at the ER and the Golgi apparatus may not be as strongly affected by cholesterol accumulation and the increase in MUFAs because we still observed stacked Golgi apparatus by EM (Fig S6)

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