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Other radicals can be created when any of these nitrogen radicals react with superoxide radicals

Also, no obvious hepatic and renal toxicity were observed among the indicated treatment groups, as assessed through the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), serum creatinine (CRE), and blood urea nitrogen (BUN) in the serum of mice (Fig

Taken together, these results demonstrate that pharmacological Ire1 inhibition suppresses lipid peroxidation induced by renal IRI in vivo, and through this mechanism alleviates renal damages caused by IRI