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( Anaesthesia, 2021 ) report that the epidemiology of local anesthetic systemic toxicity (LAST) is shifting, with delayed onset increasingly common, a growing proportion of cases arising from fascial plane and field blocks, and more events occurring outside the operating room and involving non-anesthesiologists

The enzyme that makes acetylcholine from acetyl groups and choline is the choline acetyl transferase
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Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH, Schuster D, Kopp B, Bauer R, Stuppner H, Dirsch VM, Atanasov AG