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Targeting ANGPTL3 mRNA by the antisense oligonucleotide, named as ANGPTL3-L Rx , causes reductions in the levels of ANGPTL3 protein by 46.6%84.5%, TG by 33.2%63.1%, LDL-Cs by 1.3%32.9%, VLDL-C by 27.9%60.0%, non-HDL-C by10.0%36.6%, apoB by 3.4%25.7%, and apoCIII by18.9%58.8% in mice (Graham et al., 2017)

During the Maillard reaction stage, highly reactive carbonyl compounds are formed, including glyoxal, methylglyoxal, or 3-deoxyglucosone (Wells-Knecht et al., 1995