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[5] When used for anemia it is recommended that pernicious anemia as a cause be ruled out first

Further studies identified the dependence of ROS-induced apoptosis on the persistent activation of pro-apoptotic mitogen-activated protein kinase (MAPK) pathways (cJun N-terminal kinases [JNKs] and p38), which modulated the phosphorylation of mitochondrial pro-apoptotic and anti-apoptotic proteins [26, 27]

Vitamin C is a key cofactor: it contributes to collagen synthesis and enhances the benefits of a formula combining both active ingredients