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The major portion is excreted within the first 24 hours

Paracetamol (5001000 mg up to four times daily, maximum 4 g in 24 hours) is generally the safest first-line option

These two enzymatic reactions together provide the necessary lipid substrates for ferroptosis ( 2

It is known that insulin is involved in neuronal survival, synaptic plasticity, memory, and cognitive function in the central nervous system (CNS), and existing hypotheses suggest that similar to diabetic neuropathy, impaired insulin signalling pathways due to elevated blood glucose and lipids may be the main metabolic mechanism that induces the occurrence of diabetic cognitive dysfunction (6)