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Ubiquitin, cellular inclusions and their role in neurodegeneration

Additionally, gut microbiota alterations impact the efficiency of bile acid absorption in the ileum, reducing the activity of the apical sodium-dependent bile acid transporter (ASBT), leading to an increased flow of bile acids into the colon (54)

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Pharmacokinetic aspects are determined by general processes, such as transfer across membranes, metabolism and renal elimination, which apply irrespective of the pharmacodynamic properties
