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Here we review a dozen promising IN peptide therapeutics in preclinical and clinical development for neurodegenerative (Alzheimers, Parkinsons), neuropsychiatric (depression, PTSD, schizophrenia), and neurodevelopmental disorders (autism), with insulin, NAP (davunetide), IGF-1, PACAP, NPY, oxytocin, and GLP-1 agonists prominent among them

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Additionally, micronutrient imbalanceswhether deficiencies or excessesaffect thyroid hormone synthesis, immune regulation, and the progression of autoimmunity

Future research should focus on elucidating the precise mechanisms underlying PD tremor and developing novel therapeutic strategies with regional specificity that can effectively control tremor while avoiding systemic cholinergic side effects