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Under these resultant stringent conditions restricting methionine and/or SAM, we report an unforeseen metabolic role of mitochondria in adapting to cellular SAM depletion

Hou Z, Lambert JD, Chin KV, Yang CS (2004) Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention

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43,44 A couple of uncontrolled studies in healthy volunteers showed significant homocysteine-lowering effects of acute administration of NAC, 7200 mg within 24 hours, 45 and 12004000 mg once, 44 with average reductions of 44% and 22%, respectively
