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Studies have demonstrated that certain nanoparticles, such as mesoporous silica nanoparticles functionalized with cell-penetrating peptides, can effectively travel across the BBB and deliver therapeutic agents to the brain (192)
Plasma kallikrein activity also showed dose-dependent reduction, closely correlating with the decrease in total plasma kallikrein protein levels
The patient was assessed for side effects, and patch stability was visually confirmed on a daily basis
2014;307:L86876
