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Heart-Related Symptoms If your heart is the source of your chest pain, you may experience the following additional symptoms (x, x): Pressure, fullness, squeezing, burning or tightness in your chest Crushing or searing pain that moves to your back, neck, jaw, shoulders and one or both arms Pain that lasts more than a few minutes, gets worse with activity, goes away and comes back, or varies in intensity Shortness of breath Cold sweats or hot flashes Dizziness or weakness Nausea and vomiting Fatigue Sudden heaviness, weakness or aching in one or both arms A sour taste in your mouth or a sensation of food re-entering your mouth Trouble swallowing Pain that gets better or worse when you change your position Pain that intensifies when you breathe deeply or cough Tenderness when you push on your chest Persistent pain Lung-Related Symptoms Lung discomfort or difficulty breathing may feel similar to a heart attack and will likely worsen during activity and improve when resting

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In breast cancer, LOX-induced collagen crosslinking increases stiffness, 1 integrin clustering, PI3K signalling and focal adhesion formation to drive invasion and tumour progression (FIG