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Different mushrooms have various phytochemical compounds, particularly polysaccharides that possess scavenging and antioxidant activity to help against immune diseases, as shown by in vitro studies

We also found the inverse associations of serum bilirubin with high sensitivity C-reactive protein, HbA1c and the prevalence of type 2 diabetes in approximately 12,500 middle-aged and elderly Japanese subjects [6], suggesting that bilirubin may prevent the development of type 2 diabetes

From the mechanism, iron accumulation in Tfh cells was regulated by the microRNA-21/3-hydroxybutyrate dehydrogenase-2 axis, which also strengthened the Fe (II)-dependent TET enzyme activity and demethylation of the BCL6 gene (119)