glutathione depletion-induced cell death depletion induces ferroptosis, autophagy, and premature senescence in retinal pigment epithelial cells β-Amyloid and Glutathione Dysregulation Cooperatively

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However, factors like stress, aging, poor diet, and environmental toxins can deplete glutathione levels

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These limitations include cytotoxicity, immune rejection, regulatory obstacles, senescence and inflammation, and limited targeting precision [10, 58, 59]