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The saturated fatty acid palmitic acid (PA) induces pro-inflammatory M1-like macrophage polarization through hypoxia-inducible factor 1, identified by increased TNF- and IL-6 production, whereas the unsaturated fatty acid oleic acid (OA) promotes anti-inflammatory M2-like macrophage differentiation, characterized by the increased expression of arginase-1, type 2 mannose receptor, and IL-10 ( Lactobacillus paracasei ) administration also increases the number of M2-like macrophages in the liver of murine steatohepatitis and alleviates steatosis ( In vivo , hepatic macrophages are stimulated by endotoxins, cytokines, lipids, and other metabolites

[Abstract] Ther Deliv

Additionally, it is believed that an excess of homocysteine (HCy) can undergo auto-oxidation, leading to the production of hydrogen peroxide [46]