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G6PD inhibition has been shown to impair cellular migration through ROS-dependent inhibition of protein phosphatases involved in cytoskeletal rearrangement, suggesting that chronic ROS accumulation in G6PD-d may inhibit B1 migration necessary for IgM OSE production 87,144,145 (Fig

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In postmenopausal women, estrogen therapy decreased the expression of genes involved in lipogenesis including acetyl-coenzyme A (CoA) carboxylate- and -, sterol regulatory element-binding protein 1c (SREBP-1c), stearoyl-CoA desaturase, lipoprotein lipase (LPL), FAS, fatty acid desaturase, and peroxisome proliferator-activated receptor (PPAR)- (146, 147)

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