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Proc Natl Acad Sci USA 108:86748679 Cluntun AA, Lukey MJ, Cerione RA, Locasale JW (2017) Glutamine metabolism in cancer: understanding the heterogeneity

This process primarily facilitates the transcriptional priming signal necessary for inflammasome activation and does not directly induce the secretion of mature cytokines

Key facts from Pickarts original studies: GHK-Cu exists in the plasma of all healthy adults The concentration decreases with age , from ~200 ng/ml in 20-year-olds to ~80 ng/ml in 60-year-olds This decline correlates with the age-related loss of regenerative capacity of tissue Cu is essential for the biological activity, GHK without copper has a dramatically weaker effect These original observations launched a 50-year research program that today covers thousands of publications in dermatology, wound healing, ageing research and regenerative medicine