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15,73,75 The olfactory region is considered the main region for the nose-to-brain delivery and provides a direct route that involves mechanisms of extracellular/paracellular diffusion and intracellular absorption into the olfactory neurons

Acknowledgements We would like to sincerely appreciate the staff of the Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran where data curation was taken place

Taddio, A

Brain-derived neurotrophic factor induces rapid and transient release of glutamate through the non-exocytotic pathway from cortical neurons
