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Description
Stress response patterns of plasma corticosterone, prolactin, and growth hormone in the rat, following handling or exposure to novel environment

3.1 Age-related macrostructural WM changes A variety of age-related macrostructural WM changes, including reduced WM volume, WM lesions, disrupted WM integrity, and subsequent cortical disconnection have all been observed in normal aging brains (Caligiuri et al., 2015)

Data Availability: All relevant data are within the paper

Targeted Nrf2 may be an effective treatment