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This avalanche of soluble protofibrils is often believed to be more toxic than the stable full length cross-beta fibrils owing to their membrane permeabilization capability and interaction with various cellular organelles (Winner et al., 2011)

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Vidal-Alaball J, Butler CC, Potter CC (2006) Comparing costs of intramuscular and oral vitamin B12 administration in primary care: a cost-minimization analysis