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Limited independent replication many important observations have not been replicated by teams outside the original research school, which weakens their credibility

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Figure 2 3.1 Fibroblasts Cancer-associated fibroblasts (CAFs) are the most abundant components in tumour stroma, affecting tumour angiogenesis, signal transduction, metabolism, immunosuppression, and chemotherapy resistance by secreting various growth factors, inflammatory mediators, and matrix proteins

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