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As a precursor to key neurotransmitters like dopamine and norepinephrine, it helps maintain mental clarity and alertness during periods of physical exertion, fatigue, or high cognitive demand

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Ethics declarations Ethics approval and consent to participate Manuscripts reporting studies involving human participants, human data, or human tissue must: The procedures and data collections in human study have been approved by Institutional Review Board of National Taiwan University Hospital (201507055MINC, 201712030RIND), and all participants signed a written informed consent form

49,51,52 In addition, imbalanced glutamate and GABA activity may contribute to a link between depression and chronic pain