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While this is a necessary first step, it frequently creates highly reactive, electrophilic intermediate metabolites that are actually more toxic and dangerous than the original parent compound
Arch Biochem Biophys 617:4859 Brigelius-Flohe R, Maiorino M (2013) Glutathione peroxidases
Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan
Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems
